UniProt Q9NZN5
Rho guanine nucleotide exchange factor 12 (Q9NZN5)
Rho guanine nucleotide exchange factor 12 (UniProt Q9NZN5): 8 experimental structures and 1 predicted model on GenesisL1, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NZN5
- Protein
- Rho guanine nucleotide exchange factor 12
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 21 · 1 record with a druggable one
Structures
9 records of Q9NZN5 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TXD | Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF | x-ray diffraction | A | — | 1 (best 0.32) |
| 1TXD | Crystal structure of the DH/PH domains of leukemia-associated rhogef | x-ray diffraction | A | — | — |
| 1X86 | Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA | x-ray diffraction | A, C, E, G | — | 20 (best 0.81) |
| 1X86 | Crystal structure of the DH/PH domains of leukemia-associated rhogef in complex with rhoa | x-ray diffraction | A, C, E, G | — | — |
| 2OMJ | solution structure of LARG PDZ domain | solution nmr | A | — | — |
| 2OMJ | Solution structure of larg PDZ domain | solution nmr | A | — | — |
| 2OS6 | Solution structure of LARG PDZ domain in complex with C-terminal octa-peptide of Plexin B1 | solution nmr | A | — | — |
| 2OS6 | Solution structure of larg PDZ domain in complex with C-terminal octa- peptide of plexin B1 | solution nmr | A | — | — |
| Q9NZN5 | AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 12 (Q9NZN5) | predicted | A | — | — |
Experiment against prediction
- 1X86 chain E against the predicted model Q9NZN5: TM-score 0.98, RMSD 1.08 Å
- 1X86 chain E against the predicted model Q9NZN5: TM-score 0.98, RMSD 1.08 Å
- 1X86 chain A against the predicted model Q9NZN5: TM-score 0.94, RMSD 1.82 Å
- 1X86 chain A against the predicted model Q9NZN5: TM-score 0.94, RMSD 1.82 Å
- 1X86 chain G against the predicted model Q9NZN5: TM-score 0.93, RMSD 1.89 Å
- 1X86 chain G against the predicted model Q9NZN5: TM-score 0.93, RMSD 1.89 Å
- 1X86 chain C against the predicted model Q9NZN5: TM-score 0.91, RMSD 2.23 Å
- 1X86 chain C against the predicted model Q9NZN5: TM-score 0.91, RMSD 2.23 Å
- 2OMJ chain A against the predicted model Q9NZN5: TM-score 0.81, RMSD 2.11 Å
- 2OMJ chain A against the predicted model Q9NZN5: TM-score 0.81, RMSD 2.11 Å
Elsewhere
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