MolNFT v1 · #47219 · protein

Crystal structure of M37 lipase

2ORY: “Crystal structure of M37 lipase”. X-ray diffraction, 6 pockets (best druggability 0.76). MolNFT v1 #47219 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ORY
Type: protein
Length: 679 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipase
EC: 3.1.1.3
UniProt: Q5DRN8
Pockets: 6 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lipase (EC 3.1.1.3)	protein	335	40% helix, 19% strand	Q5DRN8
B	Lipase (EC 3.1.1.3)	protein	344	42% helix, 17% strand	Q5DRN8

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	93	0.76	0.97	29	empty
2	817	0.76	0.80	67	empty
3	82	0.38	0.77	14	empty
4	93	0.37	0.76	18	empty
5	54	0.33	0.76	11	empty

Interfaces

1 interface between chains.

A–B · 1845 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

2ORY · Crystal structure of M37 lipase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5DRN8
Elsewhere: RCSB PDB 2ORY · PDBe 2ORY · UniProt Q5DRN8

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