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Crystal structure of M37 lipase
Analyse Crystal structure of M37 lipase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ORY
- Type
- protein
- Length
- 679 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lipase
- EC
- 3.1.1.3
- UniProt
- Q5DRN8
- Pockets
- 6 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lipase (EC 3.1.1.3) | protein | 335 | 40% helix, 19% strand | Q5DRN8 |
| B | Lipase (EC 3.1.1.3) | protein | 344 | 42% helix, 17% strand | Q5DRN8 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.76 | 0.97 | 29 | empty |
| 2 | 817 | 0.76 | 0.80 | 67 | empty |
| 3 | 82 | 0.38 | 0.77 | 14 | empty |
| 4 | 93 | 0.37 | 0.76 | 18 | empty |
| 5 | 54 | 0.33 | 0.76 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 1845 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2ORY · Crystal structure of M37 lipase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5DRN8
- Elsewhere: RCSB PDB 2ORY · PDBe 2ORY · UniProt Q5DRN8
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