MolNFT v1 · #47218 · protein
Structural basis for ligand binding and heparin mediated activation of neuropilin
2ORX · Neuropilin-1: “Structural basis for ligand binding and heparin mediated activation of neuropilin”. X-ray diffraction, 3 pockets (best druggability 0.46). MolNFT v1 #47218 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2ORX
- Type
- protein
- Length
- 314 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neuropilin-1
- UniProt
- Q9QWJ9
- Pockets
- 3 · best druggability 0.46
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neuropilin-1 | protein | 314 | 5% helix, 47% strand | Q9QWJ9 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.46 | 0.76 | 23 | empty |
| 2 | 51 | 0.37 | 0.80 | 14 | empty |
| 3 | 53 | 0.29 | 0.75 | 17 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2ORX · Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin · the same entry in another collection · chain A against A, TM-score 1.00
- Q9QWJ9 · AlphaFold monomer V2.0 prediction for neuropilin-1 (Q9QWJ9) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9QWJ9
- Elsewhere: RCSB PDB 2ORX · PDBe 2ORX · UniProt Q9QWJ9
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