MolNFT v1 · #47062 · protein

Crystal structure of a putative osmotically inducible protein C (TA0195) from thermoplasma acidophilum at 1.70 a resolution

2ONF · Hypothetical protein TA0195: “Crystal structure of a putative osmotically inducible protein C (TA0195) from thermoplasma acidophilum at…”. X-ray diffraction, 1 ligand (COA), 2 pockets (best druggability 0.58). MolNFT v1 #47062 on…

PDB: 2ONF
Type: protein
Length: 280 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypothetical protein TA0195
UniProt: Q9HLN2
Ligands: COA
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Hypothetical protein TA0195	protein	140	35% helix, 41% strand	Q9HLN2

Ligands and binding sites

COA · Coenzyme A · ligand · chains A, B
EDO · 1,2-ethanediol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	126	0.58	0.84	18	empty
2	61	0.50	0.85	16	EDO

Interfaces

1 interface between chains.

A–B · 3408 Å² buried · 59 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

2ONF · Crystal structure of a putative osmotically inducible protein c (ta0195) from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HLN2
Elsewhere: RCSB PDB 2ONF · PDBe 2ONF · UniProt Q9HLN2

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