MolNFT v1 · #46953 · protein

Muts C-terminal domain fused to maltose binding protein

2OK2 · Maltose-binding periplasmic protein, DNA mismatch repair…: “Muts C-terminal domain fused to maltose binding protein”. X-ray diffraction, 2 ligands (GLC, SO4), 8 pockets (best druggability 0.71). MolNFT v1 #46953 on GenesisL1: 3D…

PDB: 2OK2
Type: protein
Length: 804 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Maltose-binding periplasmic protein, DNA mismatch repair protein muts fusion protein
UniProt: P0AEX9, P23909
Ligands: GLC, SO4
Pockets: 8 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Maltose-binding periplasmic protein, DNA mismatch repair protein muts fusion protein	protein	402	47% helix, 19% strand	P0AEX9, P23909

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A, B
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	358	0.71	0.83	53	empty
2	278	0.71	0.85	32	GLC
3	283	0.70	0.84	29	GLC
4	99	0.63	0.89	23	empty
5	145	0.43	0.75	22	empty

Interfaces

1 interface between chains.

A–B · 903 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

2OK2 · MutS C-terminal domain fused to Maltose Binding Protein · the same entry in another collection · chain A against A, TM-score 1.00
P23909 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein muts (P23909) · a predicted model of the same protein · chain A against A, TM-score 0.38

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0AEX9
Every structure of UniProt P23909
Elsewhere: RCSB PDB 2OK2 · PDBe 2OK2 · UniProt P0AEX9 · UniProt P23909

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