MolNFT v1 · #46948 · protein

Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in centrosomal localization

2OJX · SERINE/THREONINE-protein kinase PLK1: “Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in centrosomal…”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #46948 on GenesisL1…

PDB: 2OJX
Type: protein
Length: 211 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase PLK1; Synthetic peptide
EC: 2.7.11.21
UniProt: P53350
Pockets: 1 · best druggability 0.33

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase PLK1 (EC 2.7.11.21)	protein	204	27% helix, 32% strand	P53350
E	Synthetic peptide	protein	7	0% helix, 14% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.33	0.75	19	empty

Interfaces

1 interface between chains.

A–E · 319 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

2OJX · Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications… · the same entry in another collection · chain A against A, TM-score 1.00
P53350 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK1 (P53350) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53350
Elsewhere: RCSB PDB 2OJX · PDBe 2OJX · UniProt P53350

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