MolNFT v1 · #46945 · protein

X-ray structure of complex of human cyclophilin J with cyclosporin a

2OJU · Peptidyl-prolyl cis-trans isomerase-like 3: “X-ray structure of complex of human cyclophilin J with cyclosporin a”. X-ray diffraction. MolNFT v1 #46945 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2OJU
Type: protein
Length: 351 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peptidyl-prolyl cis-trans isomerase-like 3; Cyclosporin a
EC: 5.2.1.8
UniProt: Q9H2H8

Structure

x-ray diffraction · 3 distinct chains · 14% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peptidyl-prolyl cis-trans isomerase-like 3 (EC 5.2.1.8)	protein	163	14% helix, 29% strand	Q9H2H8
B	Peptidyl-prolyl cis-trans isomerase-like 3 (EC 5.2.1.8)	protein	166	14% helix, 29% strand	Q9H2H8
C, D	Cyclosporin a	protein	11	0% helix, 0% strand	—

Interfaces

2 interfaces between chains.

A–C · 529 Å² buried · 8 hydrogen bonds · protein-protein
B–D · 519 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified, 2 d-amino, 2 disulfide (nonstandard, methylation, D-amino acid, disulfide).

Compared structures

2OJU · X-ray structure of complex of human cyclophilin J with cyclosporin A · the same entry in another collection · chain A against A, TM-score 1.00
Q9H2H8 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase-like 3 (Q9H2H8) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H2H8
Elsewhere: RCSB PDB 2OJU · PDBe 2OJU · UniProt Q9H2H8

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