Research workbench
X-ray structure of complex of human cyclophilin J with cyclosporin a
Analyse X-ray structure of complex of human cyclophilin J with cyclosporin a in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OJU
- Type
- protein
- Length
- 351 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidyl-prolyl cis-trans isomerase-like 3; Cyclosporin a
- EC
- 5.2.1.8
- UniProt
- Q9H2H8
Structure
x-ray diffraction · 3 distinct chains · 14% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidyl-prolyl cis-trans isomerase-like 3 (EC 5.2.1.8) | protein | 163 | 14% helix, 29% strand | Q9H2H8 |
| B | Peptidyl-prolyl cis-trans isomerase-like 3 (EC 5.2.1.8) | protein | 166 | 14% helix, 29% strand | Q9H2H8 |
| C, D | Cyclosporin a | protein | 11 | 0% helix, 0% strand | — |
Interfaces
2 interfaces between chains.
- A–C · 529 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 519 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 modified, 2 d-amino, 2 disulfide (nonstandard, methylation, D-amino acid, disulfide).
Compared structures
- 2OJU · X-ray structure of complex of human cyclophilin J with cyclosporin A · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H2H8 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase-like 3 (Q9H2H8) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H2H8
- Elsewhere: RCSB PDB 2OJU · PDBe 2OJU · UniProt Q9H2H8
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