MolNFT v1 · #46649 · protein
Mechanosensitive channel of small conductance (mscs)
2OAU · Small-conductance mechanosensitive channel: “Mechanosensitive channel of small conductance (mscs)”. X-ray diffraction, 20 pockets (best druggability 0.73). MolNFT v1 #46649 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2OAU
- Type
- protein
- Length
- 1,778 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small-conductance mechanosensitive channel
- UniProt
- P0C0S1
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Small-conductance mechanosensitive channel | protein | 254 | 53% helix, 23% strand | P0C0S1 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 232 | 0.73 | 0.87 | 35 | empty |
| 2 | 1169 | 0.72 | 0.75 | 55 | empty |
| 3 | 494 | 0.66 | 0.77 | 52 | empty |
| 4 | 96 | 0.65 | 0.90 | 19 | empty |
| 5 | 87 | 0.64 | 0.90 | 18 | empty |
Interfaces
14 interfaces between chains.
- C–D · 2866 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 2858 Ų buried · 22 hydrogen bonds · protein-protein
- F–G · 2840 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 2714 Ų buried · 22 hydrogen bonds · protein-protein
- A–G · 2692 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 2OAU · Mechanosensitive Channel of Small Conductance (MscS) · the same entry in another collection · chain G against G, TM-score 1.00
- P0C0S1 · AlphaFold monomer V2.0 prediction for small-conductance mechanosensitive channel (P0C0S1) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0S1
- Elsewhere: RCSB PDB 2OAU · PDBe 2OAU · UniProt P0C0S1
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