MolNFT v1 · #46542 · protein

The open-cap conformation of glpg

2O7L · Protein glpg: “The open-cap conformation of glpg”. X-ray diffraction, 1 ligand (BNG), 3 pockets (best druggability 0.55). MolNFT v1 #46542 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2O7L
Type: protein
Length: 175 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein glpg
UniProt: P09391
Ligands: BNG
Pockets: 3 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein glpg	protein	175	77% helix, 0% strand	P09391

Ligands and binding sites

BNG · nonyl beta-D-glucopyranoside · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	183	0.55	0.80	33	empty
2	55	0.36	0.78	11	empty
3	71	0.35	0.76	16	empty

Compared structures

2O7L · The open-cap conformation of GlpG · the same entry in another collection · chain A against A, TM-score 1.00
P09391 · AlphaFold monomer V2.0 prediction for rhomboid protease glpg (P09391) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09391
Elsewhere: RCSB PDB 2O7L · PDBe 2O7L · UniProt P09391

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.