MolNFT v1 · #46386 · protein
Crystal structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 3 (MAP3K3B-phox)
2O2V · Dual specificity mitogen-activated protein kinase kinase 5: “Crystal structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox)…”. X-ray diffraction, 2 pockets (best druggability 0.34).…
- PDB
- 2O2V
- Type
- protein
- Length
- 174 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dual specificity mitogen-activated protein kinase kinase 5; Mitogen-activated protein…
- EC
- 2.7.12.2, 2.7.11.25
- UniProt
- Q13163, Q99759
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) | protein | 92 | 35% helix, 32% strand | Q13163 |
| B | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) | protein | 82 | 30% helix, 38% strand | Q99759 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.34 | 0.76 | 13 | empty |
| 2 | 78 | 0.31 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 597 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 2O2V · Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox… · the same entry in another collection · chain A against A, TM-score 1.00
- Q99759 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase kinase kinase 3… · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q13163 · AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13163
- Every structure of UniProt Q99759
- Elsewhere: RCSB PDB 2O2V · PDBe 2O2V · UniProt Q13163 · UniProt Q99759
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