UniProt Q13163
Dual specificity mitogen-activated protein kinase kinase 5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (UniProt Q13163): 6 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q13163
- Protein
- Dual specificity mitogen-activated protein kinase kinase 5
- Experimental structures
- 6
- Predicted models
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
7 records of Q13163 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2NPT | Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain… | x-ray diffraction | A, C | — | — |
| 2NPT | Crystal structure of the complex of human mitogen activated protein kinase kinase 5 phox domain… | x-ray diffraction | A, C | — | — |
| 2O2V | Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain… | x-ray diffraction | A | — | — |
| 2O2V | Crystal structure of the complex of human mitogen activated protein kinase kinase 5 phox domain… | x-ray diffraction | A | — | — |
| 4IC7 | Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment | x-ray diffraction | E, B | — | — |
| 4IC7 | Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment | x-ray diffraction | E, B | — | — |
| Q13163 | AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase kinase 5… | predicted | A | — | 7 (best 0.78) |
Experiment against prediction
- 2O2V chain A against the predicted model Q13163: TM-score 0.95, RMSD 1.17 Å
- 2O2V chain A against the predicted model Q13163: TM-score 0.95, RMSD 1.17 Å
- 2NPT chain A against the predicted model Q13163: TM-score 0.90, RMSD 1.53 Å
- 2NPT chain A against the predicted model Q13163: TM-score 0.90, RMSD 1.53 Å
- 2NPT chain C against the predicted model Q13163: TM-score 0.89, RMSD 1.33 Å
- 2NPT chain C against the predicted model Q13163: TM-score 0.89, RMSD 1.33 Å
- 4IC7 chain E against the predicted model Q13163: TM-score 0.86, RMSD 2.18 Å
- 4IC7 chain E against the predicted model Q13163: TM-score 0.86, RMSD 2.18 Å
- 4IC7 chain B against the predicted model Q13163: TM-score 0.79, RMSD 2.25 Å
- 4IC7 chain B against the predicted model Q13163: TM-score 0.79, RMSD 2.25 Å
Elsewhere
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