MolNFT v1 · #46362 · protein

Structure of a class III rtk signaling assembly

2O27 · Kit ligand: “Structure of a class III rtk signaling assembly”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #46362 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2O27
Type: protein
Length: 251 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kit ligand
UniProt: P20826
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kit ligand	protein	126	49% helix, 8% strand	P20826
B	Kit ligand	protein	125	48% helix, 8% strand	P20826

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.46	0.77	27	empty
2	132	0.44	0.76	27	empty

Interfaces

1 interface between chains.

A–B · 816 Å² buried · 24 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

2O27 · Structure of a class III RTK signaling assembly · the same entry in another collection · chain A against A, TM-score 1.00
P20826 · AlphaFold monomer V2.0 prediction for kit ligand (P20826) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20826
Elsewhere: RCSB PDB 2O27 · PDBe 2O27 · UniProt P20826

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