MolNFT v1 · #46000 · protein

Crystal structure of glpg, a rhomboid family intramembrane protease

2NRF · Protein glpg: “Crystal structure of glpg, a rhomboid family intramembrane protease”. X-ray diffraction, 7 pockets (best druggability 0.68). MolNFT v1 #46000 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2NRF
Type: protein
Length: 355 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein glpg
UniProt: P09391
Pockets: 7 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein glpg	protein	182	72% helix, 0% strand	P09391
B	Protein glpg	protein	173	73% helix, 0% strand	P09391

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	422	0.68	0.79	41	empty
2	322	0.60	0.77	28	empty
3	149	0.51	0.78	26	empty
4	103	0.47	0.80	23	empty
5	94	0.41	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 1127 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

2NRF · Crystal Structure of GlpG, a Rhomboid family intramembrane protease · the same entry in another collection · chain A against A, TM-score 1.00
P09391 · AlphaFold monomer V2.0 prediction for rhomboid protease glpg (P09391) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09391
Elsewhere: RCSB PDB 2NRF · PDBe 2NRF · UniProt P09391

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