MolNFT v1 · #45990 · protein

Crystal structure of FMN-bound protein MM1853 from methanosarcina mazei, pfam DUF447

2NR4 · Conserved hypothetical protein: “Crystal structure of FMN-bound protein MM1853 from methanosarcina mazei, pfam DUF447”. X-ray diffraction, 1 ligand (FMN), 4 pockets (best druggability 0.75). MolNFT v1 #45990 on GenesisL1: 3D…

PDB: 2NR4
Type: protein
Length: 373 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Conserved hypothetical protein
UniProt: Q8PVV4
Ligands: FMN
Pockets: 4 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Conserved hypothetical protein	protein	191	40% helix, 32% strand	Q8PVV4
B	Conserved hypothetical protein	protein	182	38% helix, 35% strand	Q8PVV4

Ligands and binding sites

FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	505	0.75	0.83	51	empty
2	338	0.65	0.80	31	FMN
3	429	0.62	0.77	38	FMN
4	74	0.29	0.72	19	empty

Interfaces

1 interface between chains.

A–B · 1662 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

2NR4 · Crystal structure of FMN-bound protein MM1853 from Methanosarcina mazei, Pfam DUF447 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8PVV4
Elsewhere: RCSB PDB 2NR4 · PDBe 2NR4 · UniProt Q8PVV4

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