MolNFT v1 · #45986 · protein

TRNA-guanine transglycosylase (tgt) mutant in complex with 7-deaza-7- aminomethyl-guanine

2NQZ · Queuine tRNA-ribosyltransferase: “TRNA-guanine transglycosylase (tgt) mutant in complex with 7-deaza-7- aminomethyl-guanine”. X-ray diffraction, 2 ligands (PRF, ZN), 2 pockets (best druggability 0.61). MolNFT v1 #45986 on GenesisL1…

PDB: 2NQZ
Type: protein
Length: 360 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Queuine tRNA-ribosyltransferase
EC: 2.4.2.29
UniProt: P28720
Ligands: PRF, ZN
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Queuine tRNA-ribosyltransferase (EC 2.4.2.29)	protein	360	47% helix, 18% strand	P28720

Ligands and binding sites

PRF · 7-deaza-7-aminomethyl-guanine · ligand · chains A
ZN · Zinc ion · metal · chains A
GOL · Glycerol · additive · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	185	0.61	0.83	32	PRF, GOL
2	59	0.28	0.74	18	GOL

Compared structures

2NQZ · Trna-guanine transglycosylase (TGT) mutant in complex with 7-deaza-7-aminomethyl-guanine · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28720
Elsewhere: RCSB PDB 2NQZ · PDBe 2NQZ · UniProt P28720

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