MolNFT v1 · #45908 · protein + RNA
Structure of ribosome-bound cricket paralysis virus ires RNA
2NOQ · Crpv ires: “Structure of ribosome-bound cricket paralysis virus ires RNA”. Electron microscopy, 20 pockets (best druggability 0.70). MolNFT v1 #45908 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2NOQ
- Type
- protein + RNA
- Length
- 845 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Crpv ires; 18S ribosomal RNA; 25S ribosomal RNA; 40S ribosomal protein S5; 60S ribosomal…
- UniProt
- P26783, P53030, Q3E757
- Pockets
- 20 · best druggability 0.70
Structure
electron microscopy · 8 distinct chains · 32% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Crpv ires | rna | 190 | — | — |
| B | 18S ribosomal RNA | rna | 46 | — | — |
| C | 18S ribosomal RNA | rna | 13 | — | — |
| D | 18S ribosomal RNA | rna | 15 | — | — |
| E | 25S ribosomal RNA | rna | 53 | — | — |
| F | 40S ribosomal protein S5 | protein | 150 | 54% helix, 9% strand | P26783 |
| G | 60S ribosomal protein L1 | protein | 213 | 39% helix, 25% strand | P53030 |
| H | 60S ribosomal protein L11-B | protein | 165 | 2% helix, 5% strand | Q3E757 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.70 | 0.97 | 22 | empty |
| 2 | 723 | 0.69 | 0.77 | 71 | empty |
| 3 | 113 | 0.65 | 0.88 | 30 | empty |
| 4 | 85 | 0.64 | 0.90 | 18 | empty |
| 5 | 320 | 0.62 | 0.80 | 26 | empty |
Interfaces
9 interfaces between chains.
- E–G · 1338 Ų buried · 72 hydrogen bonds · protein-nucleic
- C–D · 914 Ų buried · 66 hydrogen bonds · nucleic-nucleic
- A–B · 598 Ų buried · 106 hydrogen bonds · nucleic-nucleic
- A–G · 542 Ų buried · 63 hydrogen bonds · protein-nucleic
- A–F · 372 Ų buried · 19 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26783
- Every structure of UniProt P53030
- Every structure of UniProt Q3E757
- Elsewhere: RCSB PDB 2NOQ · PDBe 2NOQ · UniProt P26783 · UniProt P53030 · UniProt Q3E757
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.