MolNFT v1 · #45871 · protein
Structure of inhibitor binding to carbonic anhydrase II
2NNO · Carbonic anhydrase 2: “Structure of inhibitor binding to carbonic anhydrase II”. X-ray diffraction, 2 ligands (M28, ZN), 1 pocket (best druggability 0.57). MolNFT v1 #45871 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2NNO
- Type
- protein
- Length
- 259 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbonic anhydrase 2
- EC
- 4.2.1.1
- UniProt
- P00918
- Ligands
- M28, ZN
- Pockets
- 1 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 14% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carbonic anhydrase 2 (EC 4.2.1.1) | protein | 259 | 14% helix, 31% strand | P00918 |
Ligands and binding sites
- M28 · 3-[4-(aminosulfonyl)phenyl]propanoic acid · ligand · 2 copies · chains A
- ZN · Zinc ion · metal · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 180 | 0.57 | 0.80 | 27 | M28, GOL |
Modifications
Observed in the structure: 1 modified (nonstandard).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00918
- Elsewhere: RCSB PDB 2NNO · PDBe 2NNO · UniProt P00918
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