MolNFT v1 · #45805 · protein
Crystal structure of the mcl-1:BIM BH3 complex
2NL9 · Fusion protein consisting of induced myeloid leukemia cell…: “Crystal structure of the mcl-1:BIM BH3 complex”. X-ray diffraction, 2 ligands (ZN, CL). MolNFT v1 #45805 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2NL9
- Type
- protein
- Length
- 165 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein consisting of induced myeloid leukemia cell differentiation protein mcl-1…
- UniProt
- P97287, Q07820, O43521
- Ligands
- ZN, CL
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion protein consisting of induced myeloid leukemia cell differentiation protein mcl-1 homolog | protein | 142 | 77% helix, 0% strand | P97287, Q07820 |
| B | BCL-2-like protein 11 | protein | 23 | 91% helix, 0% strand | O43521 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 1068 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (engineered).
Compared structures
- 2NL9 · Crystal structure of the Mcl-1:Bim BH3 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q07820 · AlphaFold monomer V2.0 prediction for induced myeloid leukemia cell differentiation… · a predicted model of the same protein · chain A against A, TM-score 0.94
- P97287 · AlphaFold monomer V2.0 prediction for induced myeloid leukemia cell differentiation… · a predicted model of the same protein · chain A against A, TM-score 0.94
- O43521 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 11 (O43521) · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P97287
- Every structure of UniProt Q07820
- Every structure of UniProt O43521
- Elsewhere: RCSB PDB 2NL9 · PDBe 2NL9 · UniProt P97287 · UniProt Q07820 · UniProt O43521
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