MolNFT v1 · #45680 · protein

Transmembrane domain of mouse FAS/CD95 death receptor

2NA6 · Tumor necrosis factor receptor superfamily member 6: “Transmembrane domain of mouse FAS/CD95 death receptor”. Solution nmr, 2 pockets (best druggability 0.53). MolNFT v1 #45680 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 2NA6
Type: protein
Length: 84 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tumor necrosis factor receptor superfamily member 6
UniProt: P25446
Pockets: 2 · best druggability 0.53

Structure

solution nmr · 1 distinct chain · 68% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Tumor necrosis factor receptor superfamily member 6	protein	28	68% helix, 0% strand	P25446

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	286	0.53	0.75	27	empty
2	70	0.36	0.76	14	empty

Interfaces

3 interfaces between chains.

A–C · 393 Å² buried · 0 hydrogen bonds · protein-protein
A–B · 382 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 373 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2NA6 · Transmembrane domain of mouse Fas/CD95 death receptor · the same entry in another collection · chain A against A, TM-score 1.00
P25446 · AlphaFold monomer V2.0 prediction for tumor necrosis factor receptor superfamily member 6… · a predicted model of the same protein · chain A against A, TM-score 0.41

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25446
Elsewhere: RCSB PDB 2NA6 · PDBe 2NA6 · UniProt P25446

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