MolNFT v1 · #45493 · protein
Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9)
2N4Q · Chromobox protein homolog 8: “Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9)”. Solution nmr, 1 pocket (best druggability 0.45). MolNFT v1 #45493 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2N4Q
- Type
- protein
- Length
- 94 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromobox protein homolog 8; Protein af-9
- UniProt
- Q9HC52, P42568
- Pockets
- 1 · best druggability 0.45
Structure
solution nmr · 2 distinct chains · 46% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromobox protein homolog 8 | protein | 24 | 17% helix, 13% strand | Q9HC52 |
| B | Protein af-9 | protein | 70 | 56% helix, 11% strand | P42568 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.45 | 0.79 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 576 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2N4Q · Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9) · the same entry in another collection · chain A against A, TM-score 1.00
- P42568 · AlphaFold monomer V2.0 prediction for protein af-9 (P42568) · a predicted model of the same protein · chain B against A, TM-score 0.74
- Q9HC52 · AlphaFold monomer V2.0 prediction for chromobox protein homolog 8 (Q9HC52) · a predicted model of the same protein · chain A against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HC52
- Every structure of UniProt P42568
- Elsewhere: RCSB PDB 2N4Q · PDBe 2N4Q · UniProt Q9HC52 · UniProt P42568
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