UniProt P42568
Protein AF-9 (P42568)
Protein AF-9 (UniProt P42568): 30 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P42568
- Protein
- Protein AF-9
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 21 · 4 records with a druggable one
Structures
31 records of P42568 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LM0 | Solution structure of the AF4-AF9 complex | solution nmr | A | — | — |
| 2LM0 | Solution structure of the AF4-AF9 complex | solution nmr | A | — | — |
| 2MV7 | Solution NMR structure of DOT1L in complex with AF9 (DOT1L-AF9) | solution nmr | A | — | — |
| 2MV7 | Solution NMR structure of DOT1L in complex with AF9 (DOT1L-AF9) | solution nmr | A | — | — |
| 2N4Q | Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9) | solution nmr | B | — | — |
| 2N4Q | Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9) | solution nmr | B | — | — |
| 2NDF | Solution NMR structures of AF9 yeats domain in complex with histon H3 acetylation at K18 | solution nmr | A | — | — |
| 2NDF | Solution NMR structures of AF9 yeats domain in complex with histon H3 acetylation at K18 | solution nmr | A | — | — |
| 2NDG | Solution NMR structures of AF9 yeats domain in complex with histone H3 crotonylation at K18 | solution nmr | A | — | — |
| 2NDG | Solution NMR structures of AF9 yeats domain in complex with histone H3 crotonylation at K18 | solution nmr | A | — | — |
| 4TMP | Crystal structure of AF9 YEATS bound to H3K9ac peptide | x-ray diffraction | A, C | — | — |
| 4TMP | Crystal structure of AF9 yeats bound to H3K9AC peptide | x-ray diffraction | A, C | — | — |
| 5HJB | AF9 YEATS in complex with histone H3 Crotonylation at K9 | x-ray diffraction | A | — | — |
| 5HJB | AF9 yeats in complex with histone H3 crotonylation at K9 | x-ray diffraction | A | — | — |
| 5HJD | AF9 YEATS in complex with histone H3 Crotonylation at K18 | x-ray diffraction | A, C, E, G, K, N, Q, T | CU, SO4 | 12 (best 0.67) |
| 5HJD | AF9 yeats in complex with histone H3 crotonylation at K18 | x-ray diffraction | A, C, E, G, K, N, Q, T | — | — |
| 5YYF | Crystal structure of AF9 yeats domain in complex with a peptide inhibitor "phq-H3(Q5-K9)" modified… | x-ray diffraction | A, C | PHQ, NH2, SO4, FOA | — |
| 6B7G | Solution NMR structure of BCoR in complex with AF9 (BCoR-AF9) | solution nmr | A | — | 2 (best 0.75) |
| 6B7G | Solution NMR structure of bcor in complex with AF9 (bcor-AF9) | solution nmr | A | — | — |
| 6L5Z | Crystal strucutre of AF9 yeats domain in complex with a cyclopeptide inhibitor | x-ray diffraction | A | EDX, EE0, EE3, NH2 | — |
| 6LS6 | Crystal Structure of YEATS domain of AF9 in complex with H3K9bz peptide | x-ray diffraction | A, B | — | — |
| 6LS6 | Crystal structure of yeats domain of AF9 in complex with H3K9BZ peptide | x-ray diffraction | A, B | — | — |
| 6MIL | Crystal structure of AF9 YEATS domain in complex with histone H3K9bu | x-ray diffraction | A, C | — | — |
| 6MIL | Crystal structure of AF9 yeats domain in complex with histone H3K9BU | x-ray diffraction | A, C | — | — |
| 6MIM | Crystal structure of AF9 YEATS domain Y78W mutant in complex with histone H3K9cr | x-ray diffraction | A, C | — | 3 (best 0.66) |
| 6MIM | Crystal structure of AF9 yeats domain Y78W mutant in complex with histone H3K9CR | x-ray diffraction | A, C | — | — |
| 7EIC | Crystal structure of AF9 yeats domain in complex with H4K5ACK8AC peptide | x-ray diffraction | A, B | — | — |
| 7EID | Crystal structure of AF9 YEATS domain in complex with H4K8acK12ac peptide | x-ray diffraction | A, B | — | 1 (best 0.31) |
| 7EID | Crystal structure of AF9 yeats domain in complex with H4K8ACK12AC peptide | x-ray diffraction | A, B | — | — |
| 8TLX | Crystal structure of MBP and AF9 AHD fusion protein 3AQA in complex with peptidomimetic inhibitor… | x-ray diffraction | A | GLC | 3 (best 0.68) |
| P42568 | AlphaFold monomer V2.0 prediction for protein af-9 (P42568) | predicted | A | — | — |
Ligands
- NH2 · Amino group · in 2 records
- SO4 · Sulfate ion · in 2 records
- CU · Copper (II) ion · in 1 record
- EDX · (2~{S})-6-carbamimidamido-2-(phenylmethoxycarbonylamino)hexanoic acid · in 1 record
- EE0 · (2~{R})-2-azanylpentanoic acid · in 1 record
- EE3 · (2~{S})-2-azanyl-6-(1,3-oxazol-5-ylcarbonylamino) hexanoic acid · in 1 record
- FOA · 2-furoic acid · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
- PHQ · benzyl chlorocarbonate · in 1 record
Experiment against prediction
- 4TMP chain A against the predicted model P42568: TM-score 0.99, RMSD 0.37 Å
- 4TMP chain A against the predicted model P42568: TM-score 0.99, RMSD 0.37 Å
- 6MIL chain A against the predicted model P42568: TM-score 0.99, RMSD 0.40 Å
- 6MIL chain A against the predicted model P42568: TM-score 0.99, RMSD 0.40 Å
- 6LS6 chain B against the predicted model P42568: TM-score 0.99, RMSD 0.40 Å
- 6LS6 chain B against the predicted model P42568: TM-score 0.99, RMSD 0.40 Å
- 7EIC chain A against the predicted model P42568: TM-score 0.99, RMSD 0.43 Å
- 5YYF chain A against the predicted model P42568: TM-score 0.99, RMSD 0.43 Å
- 6LS6 chain A against the predicted model P42568: TM-score 0.99, RMSD 0.44 Å
- 6LS6 chain A against the predicted model P42568: TM-score 0.99, RMSD 0.44 Å
Elsewhere
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