MolNFT v1 · #45414 · protein

Spatial structure of HER2/ERBB2 dimeric transmembrane domain in the presence of cytoplasmic juxtamembrane domains

2N2A · Receptor tyrosine-protein kinase erbb-2: “Spatial structure of HER2/ERBB2 dimeric transmembrane domain in the presence of cytoplasmic juxtamembrane…”. Solution nmr, 2 pockets (best druggability 0.57). MolNFT v1 #45414 on GenesisL1…

PDB: 2N2A
Type: protein
Length: 116 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor tyrosine-protein kinase erbb-2
UniProt: P04626
Pockets: 2 · best druggability 0.57

Structure

solution nmr · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Receptor tyrosine-protein kinase erbb-2	protein	58	72% helix, 0% strand	P04626

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	308	0.57	0.76	30	empty
2	57	0.39	0.79	12	empty

Interfaces

1 interface between chains.

A–B · 715 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2N2A · Spatial structure of HER2/ErbB2 dimeric transmembrane domain in the presence of… · the same entry in another collection · chain A against A, TM-score 1.00
P04626 · AlphaFold monomer V2.0 prediction for receptor tyrosine-protein kinase erbb-2 (P04626) · a predicted model of the same protein · chain B against A, TM-score 0.57

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04626
Elsewhere: RCSB PDB 2N2A · PDBe 2N2A · UniProt P04626

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