MolNFT v1 · #45347 · protein
MDMX-298
2N06 · Protein MDM4: “MDMX-298”. Solution nmr, 1 ligand (44Z), 1 pocket (best druggability 0.60). MolNFT v1 #45347 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2N06
- Type
- protein
- Length
- 89 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein MDM4
- UniProt
- O15151
- Ligands
- 44Z
- Pockets
- 1 · best druggability 0.60
Structure
solution nmr · 1 distinct chain · 49% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein MDM4 | protein | 89 | 49% helix, 12% strand | O15151 |
Ligands and binding sites
- 44Z · 4-[[(4S,5R)-5-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 197 | 0.60 | 0.81 | 25 | 44Z |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15151
- Elsewhere: RCSB PDB 2N06 · PDBe 2N06 · UniProt O15151
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