MolNFT v1 · #45057 · protein

A subunit of 26S proteasome lid complex

2MR3 · 26S proteasome regulatory subunit RPN9: “A subunit of 26S proteasome lid complex”. Solution nmr, 3 pockets (best druggability 0.45). MolNFT v1 #45057 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2MR3
Type: protein
Length: 356 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 26S proteasome regulatory subunit RPN9
UniProt: Q04062
Pockets: 3 · best druggability 0.45

Structure

solution nmr · 1 distinct chain · 65% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	26S proteasome regulatory subunit RPN9	protein	356	65% helix, 3% strand	Q04062

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.45	0.81	17	empty
2	131	0.44	0.76	26	empty
3	76	0.37	0.77	19	empty

Compared structures

2MR3 · A subunit of 26S proteasome lid complex · the same entry in another collection · chain A against A, TM-score 1.00
Q04062 · AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN9 (Q04062) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q04062
Elsewhere: RCSB PDB 2MR3 · PDBe 2MR3 · UniProt Q04062

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.