MolNFT v1 · #45032 · protein
Solution structure of Y125F mutant of ERF1 N-domain
2MQ6 · Eukaryotic peptide chain release factor subunit 1: “Solution structure of Y125F mutant of ERF1 N-domain”. Solution nmr, 2 pockets (best druggability 0.45). MolNFT v1 #45032 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2MQ6
- Type
- protein
- Length
- 142 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic peptide chain release factor subunit 1
- UniProt
- P62495
- Pockets
- 2 · best druggability 0.45
Structure
solution nmr · 1 distinct chain · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic peptide chain release factor subunit 1 | protein | 142 | 46% helix, 16% strand | P62495 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.45 | 0.82 | 17 | empty |
| 2 | 64 | 0.39 | 0.79 | 18 | empty |
Compared structures
- 2MQ6 · Solution structure of Y125F mutant of eRF1 N-domain · the same entry in another collection · chain A against A, TM-score 1.00
- P62495 · AlphaFold monomer V2.0 prediction for eukaryotic peptide chain release factor subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62495
- Elsewhere: RCSB PDB 2MQ6 · PDBe 2MQ6 · UniProt P62495
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