MolNFT v1 · #45029 · protein

NMR structure of the C3 domain of human cardiac myosin binding protein-C with a hypertrophic cardiomyopathy-related mutation R502W.

2MQ3 · Myosin-binding protein C, cardiac-type: “NMR structure of the C3 domain of human cardiac myosin binding protein-C with a hypertrophic…”. Solution nmr, 1 pocket (best druggability 0.38). MolNFT v1 #45029 on GenesisL1: 3D structure…

PDB: 2MQ3
Type: protein
Length: 95 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin-binding protein C, cardiac-type
UniProt: Q14896
Pockets: 1 · best druggability 0.38

Structure

solution nmr · 1 distinct chain · 0% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myosin-binding protein C, cardiac-type	protein	95	0% helix, 38% strand	Q14896

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.38	0.78	15	empty

Compared structures

2MQ3 · NMR structure of the c3 domain of human cardiac myosin binding protein-c with a… · the same entry in another collection · chain A against A, TM-score 1.00
Q14896 · AlphaFold monomer V2.0 prediction for myosin-binding protein C, cardiac-type (Q14896) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14896
Elsewhere: RCSB PDB 2MQ3 · PDBe 2MQ3 · UniProt Q14896

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