UniProt Q14896
Myosin-binding protein C, cardiac-type (Q14896)
Myosin-binding protein C, cardiac-type (UniProt Q14896): 30 experimental structures and 1 predicted model on GenesisL1, 45 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14896
- Protein
- Myosin-binding protein C, cardiac-type
- Experimental structures
- 30
- Predicted models
- 1
- Pockets
- 45 · 7 records with a druggable one
Structures
31 records of Q14896 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GXE | Central domain of cardiac myosin binding protein C | solution nmr | A | — | — |
| 1GXE | Central domain of cardiac myosin binding protein C | solution nmr | A | — | — |
| 1PD6 | The NMR structure of domain C2 of human cardiac Myosin Binding Protein C | solution nmr | A | — | — |
| 1PD6 | The NMR structure of domain C2 of human cardiac myosin binding protein C | solution nmr | A | — | — |
| 2AVG | NMR structure of cC1 domain from Human Cardiac Myosin Binding Protein C | solution nmr | A | — | — |
| 2AVG | NMR structure of CC1 domain from human cardiac myosin binding protein C | solution nmr | A | — | — |
| 2K1M | 3D NMR structure of domain cC0 of cardiac myosin binding protein C (MyBPC) | solution nmr | A | — | — |
| 2K1M | 3D NMR structure of domain CC0 of cardiac myosin binding protein C (mybpc) | solution nmr | A | — | — |
| 2MQ0 | NMR structure of the c3 domain of human cardiac myosin binding protein-c | solution nmr | A | — | — |
| 2MQ0 | NMR structure of the C3 domain of human cardiac myosin binding protein-C | solution nmr | A | — | — |
| 2MQ3 | NMR structure of the c3 domain of human cardiac myosin binding protein-c with a hypertrophic… | solution nmr | A | — | — |
| 2MQ3 | NMR structure of the C3 domain of human cardiac myosin binding protein-C with a hypertrophic… | solution nmr | A | — | — |
| 2V6H | Crystal structure of the C1 domain of cardiac myosin binding protein-C | x-ray diffraction | A | — | — |
| 2V6H | Crystal structure of the C1 domain of cardiac myosin binding protein-C | x-ray diffraction | A | — | — |
| 3CX2 | Crystal structure of the C1 domain of cardiac isoform of myosin binding protein-C at 1.3A | x-ray diffraction | A | — | — |
| 3CX2 | Crystal structure of the C1 domain of cardiac isoform of myosin binding protein-C at 1.3A | x-ray diffraction | A | — | — |
| 5K6P | The NMR structure of the m domain tri-helix bundle and C2 of human cardiac Myosin Binding Protein C | solution nmr | A | — | — |
| 5K6P | The NMR structure of the M domain tri-helix bundle and C2 of human cardiac myosin binding protein C | solution nmr | A | — | — |
| 6CXI | Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 1 | electron microscopy | G, H, I, J, K, L, M, N, O, P, Q | — | — |
| 6CXI | Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 1 | electron microscopy | G, H, I, J, K, L, M, N, O, P, Q | — | — |
| 6CXJ | Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 2 | electron microscopy | G, H, I, J, K, L, M, N, O, P, Q | — | 7 (best 0.69) |
| 6CXJ | Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 2 | electron microscopy | G, H, I, J, K, L, M, N, O, P, Q | — | — |
| 6G2T | human cardiac myosin binding protein C C1 Ig-domain bound to native cardiac thin filament | electron microscopy | G, H, I, J, K, L | — | 6 (best 0.72) |
| 6G2T | Human cardiac myosin binding protein C C1 ig-domain bound to native cardiac thin filament | electron microscopy | G, H, I, J, K, L | — | — |
| 7LRG | Filamentous actin decorated with human cardiac myosin binding protein C C2 domain | electron microscopy | G, H, I, J, K, L | — | 7 (best 0.69) |
| 7LRG | Filamentous actin decorated with human cardiac myosin binding protein C C2 domain | electron microscopy | G, H, I, J, K, L | — | — |
| 7TIJ | Cardiac F-actin decorated with regulatory M-domain of cardiac myosin binding protein C | electron microscopy | G, H, I, J, K, L | — | 7 (best 0.85) |
| 7TIT | Cardiac thin filament decorated with regulatory M-domain of cardiac myosin binding protein C | electron microscopy | G, H, I, J, K, L | — | 6 (best 0.86) |
| 7TJ7 | Cardiac thin filament decorated with C1 Ig-domain and regulatory M-domain of cardiac myosin binding… | electron microscopy | G, H, I, J, K, L, M, N, O, P, Q, R | — | 5 (best 0.86) |
| 8G4L | Cryo-EM structure of the human cardiac myosin filament | electron microscopy | bo, ao, o | — | — |
| Q14896 | AlphaFold monomer V2.0 prediction for myosin-binding protein C, cardiac-type (Q14896) | predicted | A | — | 7 (best 0.60) |
Experiment against prediction
- 2V6H chain A against the predicted model Q14896: TM-score 0.94, RMSD 1.22 Å
- 2V6H chain A against the predicted model Q14896: TM-score 0.94, RMSD 1.22 Å
- 6G2T chain I against the predicted model Q14896: TM-score 0.94, RMSD 1.54 Å
- 3CX2 chain A against the predicted model Q14896: TM-score 0.94, RMSD 1.29 Å
- 3CX2 chain A against the predicted model Q14896: TM-score 0.94, RMSD 1.29 Å
- 6G2T chain H against the predicted model Q14896: TM-score 0.93, RMSD 1.33 Å
- 6CXJ chain H against the predicted model Q14896: TM-score 0.93, RMSD 1.30 Å
- 6G2T chain K against the predicted model Q14896: TM-score 0.93, RMSD 1.37 Å
- 6CXJ chain K against the predicted model Q14896: TM-score 0.93, RMSD 1.12 Å
- 6G2T chain L against the predicted model Q14896: TM-score 0.93, RMSD 1.16 Å
Elsewhere
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