MolNFT v1 · #45025 · protein
Atomic model of the abeta D23N "iowa" mutant using solid-state NMR, EM and rosetta modeling
2MPZ · Amyloid beta A4 protein: “Atomic model of the abeta D23N "iowa" mutant using solid-state NMR, EM and rosetta modeling”. Solid-state nmr, 7 pockets (best druggability 0.77). MolNFT v1 #45025 on GenesisL1: 3D structure, binding sites…
- PDB
- 2MPZ
- Type
- protein
- Length
- 702 residues
- Chains
- 27
- Method
- solid-state nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Amyloid beta A4 protein
- UniProt
- P05067
- Pockets
- 7 · best druggability 0.77
Structure
solid-state nmr · 1 distinct chain · 0% helix, 58% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a | Amyloid beta A4 protein | protein | 26 | 0% helix, 58% strand | P05067 |
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 393 | 0.77 | 0.86 | 78 | empty |
| 2 | 322 | 0.76 | 0.88 | 65 | empty |
| 3 | 441 | 0.76 | 0.85 | 78 | empty |
| 4 | 1062 | 0.71 | 0.75 | 77 | empty |
| 5 | 1132 | 0.69 | 0.74 | 81 | empty |
Interfaces
120 interfaces between chains.
- D–G · 1140 Ų buried · 33 hydrogen bonds · protein-protein
- G–J · 1136 Ų buried · 33 hydrogen bonds · protein-protein
- P–S · 1136 Ų buried · 33 hydrogen bonds · protein-protein
- U–X · 1135 Ų buried · 35 hydrogen bonds · protein-protein
- M–P · 1135 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 2MPZ · Atomic model of the Abeta D23N Iowa" mutant using solid-state NMR · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05067
- Elsewhere: RCSB PDB 2MPZ · PDBe 2MPZ · UniProt P05067
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.