Zinc induced dimer of the metal binding domain 1-16 of human amyloid beta-peptide with ALZHEIMER'S disease pathogenic english mutation H6R

Structure

solution nmr · 1 distinct chain · 19% helix, 0% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · 2 copies · chains A, B
• ZN · Zinc ion · metal · chains A, B
• NH2 · Amino group · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 92 Ų buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent (covalent ligand).

Compared structures

• 2MGT · Zinc induced dimer of the metal binding domain 1-16 of human amyloid beta-peptide with… · the same entry in another collection · chain A against A, TM-score 1.00
• P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain A against A, TM-score 0.25

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P05067
• Elsewhere: RCSB PDB 2MGT · PDBe 2MGT · UniProt P05067