MolNFT v1 · #44737 · protein

Solution structure of CXCL5

2MGS · C-X-C motif chemokine 5: “Solution structure of CXCL5”. Solution nmr, 5 pockets (best druggability 0.61). MolNFT v1 #44737 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2MGS
Type: protein
Length: 142 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C-X-C motif chemokine 5
UniProt: P42830
Pockets: 5 · best druggability 0.61

Structure

solution nmr · 1 distinct chain · 21% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	C-X-C motif chemokine 5	protein	71	21% helix, 24% strand	P42830

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	196	0.61	0.82	29	empty
2	69	0.48	0.84	13	empty
3	65	0.36	0.78	17	empty
4	55	0.31	0.76	16	empty
5	57	0.31	0.76	15	empty

Interfaces

1 interface between chains.

A–B · 863 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2MGS · Solution structure of CXCL5 · the same entry in another collection · chain A against A, TM-score 1.00
P42830 · AlphaFold monomer V2.0 prediction for C-X-C motif chemokine 5 (P42830) · a predicted model of the same protein · chain B against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42830
Elsewhere: RCSB PDB 2MGS · PDBe 2MGS · UniProt P42830

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