MolNFT v1 · #44701 · protein
NMR solution structures of FRS2A ptb domain with neurotrophin receptor trkb
2MFQ · Fibroblast growth factor receptor substrate 2: “NMR solution structures of FRS2A ptb domain with neurotrophin receptor trkb”. Solution nmr. MolNFT v1 #44701 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2MFQ
- Type
- protein
- Length
- 138 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor substrate 2; BDNF/NT-3 growth factors receptor
- EC
- 2.7.10.1
- UniProt
- Q8WU20, Q16620
Structure
solution nmr · 2 distinct chains · 11% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor substrate 2 | protein | 115 | 13% helix, 30% strand | Q8WU20 |
| B | BDNF/NT-3 growth factors receptor (EC 2.7.10.1) | protein | 23 | 0% helix, 48% strand | Q16620 |
Interfaces
1 interface between chains.
- A–B · 1079 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2MFQ · NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WU20 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor substrate 2… · a predicted model of the same protein · chain A against A, TM-score 0.73
- Q16620 · AlphaFold monomer V2.0 prediction for BDNF/NT-3 growth factors receptor (Q16620) · a predicted model of the same protein · chain B against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WU20
- Every structure of UniProt Q16620
- Elsewhere: RCSB PDB 2MFQ · PDBe 2MFQ · UniProt Q8WU20 · UniProt Q16620
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