MolNFT v1 · #44463 · protein

NMR structure of a two-domain RNA-binding fragment of NRD1

2M88 · Protein NRD1: “NMR structure of a two-domain RNA-binding fragment of NRD1”. Solution nmr, 3 pockets (best druggability 0.54). MolNFT v1 #44463 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2M88
Type: protein
Length: 185 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein NRD1
UniProt: P53617
Pockets: 3 · best druggability 0.54

Structure

solution nmr · 1 distinct chain · 19% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein NRD1	protein	185	19% helix, 12% strand	P53617

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	258	0.54	0.76	28	empty
2	151	0.44	0.75	20	empty
3	71	0.31	0.74	15	empty

Compared structures

2M88 · NMR structure of a two-domain RNA-binding fragment of Nrd1 · the same entry in another collection · chain A against A, TM-score 1.00
P53617 · AlphaFold monomer V2.0 prediction for protein NRD1 (P53617) · a predicted model of the same protein · chain A against A, TM-score 0.42

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53617
Elsewhere: RCSB PDB 2M88 · PDBe 2M88 · UniProt P53617

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.