MolNFT v1 · #44103 · protein
Solution structure of the complex between the SGT2 homodimerization domain and the GET5 ubl domain
2LXC · Ubiquitin-like protein MDY2: “Solution structure of the complex between the SGT2 homodimerization domain and the GET5 ubl domain”. Solution nmr, 1 pocket (best druggability 0.58). MolNFT v1 #44103 on GenesisL1: 3D structure, binding…
- PDB
- 2LXC
- Type
- protein
- Length
- 229 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-like protein MDY2; Small glutamine-rich tetratricopeptide repeat-containing…
- UniProt
- Q12285, Q12118
- Pockets
- 1 · best druggability 0.58
Structure
solution nmr · 2 distinct chains · 37% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-like protein MDY2 | protein | 81 | 21% helix, 36% strand | Q12285 |
| B, C | Small glutamine-rich tetratricopeptide repeat-containing protein 2 | protein | 74 | 55% helix, 0% strand | Q12118 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.58 | 0.82 | 26 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1574 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 415 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 370 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2LXC · Solution structure of the complex between the Sgt2 homodimerization domain and the Get5… · the same entry in another collection · chain B against B, TM-score 1.00
- Q12285 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein MDY2 (Q12285) · a predicted model of the same protein · chain A against A, TM-score 0.85
- Q12118 · AlphaFold monomer V2.0 prediction for small glutamine-rich tetratricopeptide… · a predicted model of the same protein · chain B against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12285
- Every structure of UniProt Q12118
- Elsewhere: RCSB PDB 2LXC · PDBe 2LXC · UniProt Q12285 · UniProt Q12118
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