MolNFT v1 · #43894 · protein

NMR structure of a line-1 type transposase domain-containing protein 1 (L1TD1) from homo sapiens

2LR6: “NMR structure of a line-1 type transposase domain-containing protein 1 (L1TD1) from homo sapiens”. Solution nmr, 5 pockets (best druggability 0.51). MolNFT v1 #43894 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2LR6
Type: protein
Length: 176 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Line-1 type transposase domain-containing protein 1
UniProt: Q5T7N2
Pockets: 5 · best druggability 0.51

Structure

solution nmr · 1 distinct chain · 23% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Line-1 type transposase domain-containing protein 1	protein	88	23% helix, 14% strand	Q5T7N2

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.51	0.87	17	empty
2	89	0.48	0.81	17	empty
3	52	0.38	0.80	18	empty
4	69	0.38	0.78	17	empty
5	77	0.31	0.73	18	empty

Interfaces

1 interface between chains.

A–B · 2313 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

2LR6 · NMR structure of a LINE-1 type transposase domain-containing protein 1 (L1TD1) from Homo… · the same entry in another collection · chain A against A, TM-score 1.00
Q5T7N2 · AlphaFold monomer V2.0 prediction for line-1 type transposase domain- containing protein… · a predicted model of the same protein · chain A against A, TM-score 0.50

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5T7N2
Elsewhere: RCSB PDB 2LR6 · PDBe 2LR6 · UniProt Q5T7N2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.