MolNFT v1 · #4362 · protein

Human immunodeficiency virus type 1

1DLO · Human immunodeficiency virus type 1 reverse transcriptase: “Human immunodeficiency virus type 1”. X-ray diffraction, 14 pockets (best druggability 0.73). MolNFT v1 #4362 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1DLO
Type: protein
Length: 971 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human immunodeficiency virus type 1 reverse transcriptase
EC: 2.7.7.49
UniProt: P03366
Pockets: 14 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Human immunodeficiency virus type 1 reverse transcriptase (EC 2.7.7.49)	protein	556	30% helix, 20% strand	P03366
B	Human immunodeficiency virus type 1 reverse transcriptase (EC 2.7.7.49)	protein	415	34% helix, 19% strand	P03366

Pockets

14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	799	0.73	0.78	74	empty
2	478	0.66	0.78	58	empty
3	405	0.65	0.78	40	empty
4	463	0.61	0.75	53	empty
5	395	0.61	0.77	47	empty

Interfaces

1 interface between chains.

A–B · 2929 Å² buried · 44 hydrogen bonds · protein-protein

Compared structures

1DLO · Human immunodeficiency virus type 1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03366
Elsewhere: RCSB PDB 1DLO · PDBe 1DLO · UniProt P03366

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