MolNFT v1 · #43551 · protein
Solution structure of CA2+/CALMODULIN complexed with a peptide representing the calmodulin-binding domain of L-selectin
2LGF: “Solution structure of CA2+/CALMODULIN complexed with a peptide representing the calmodulin-binding domain of…”. Solution nmr, 1 ligand (CA), 1 pocket (best druggability 0.63). MolNFT v1 #43551 on GenesisL1: 3D structure, binding…
- PDB
- 2LGF
- Type
- protein
- Length
- 161 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; L-selectin
- UniProt
- P62158, P14151
- Ligands
- CA
- Pockets
- 1 · best druggability 0.63
Structure
solution nmr · 2 distinct chains · 61% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 146 | 59% helix, 3% strand | P62158 |
| B | L-selectin | protein | 15 | 87% helix, 0% strand | P14151 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 171 | 0.63 | 0.84 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1189 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2LGF · Solution structure of Ca2+/calmodulin complexed with a peptide representing the… · the same entry in another collection · chain A against A, TM-score 1.00
- P14151 · AlphaFold monomer V2.0 prediction for L-selectin (P14151) · a predicted model of the same protein · chain B against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62158
- Every structure of UniProt P14151
- Elsewhere: RCSB PDB 2LGF · PDBe 2LGF · UniProt P62158 · UniProt P14151
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