MolNFT v1 · #43511 · protein

Structure of a monomeric mutant of the HIV-1 capsid protein

2LF4 · Gag polyprotein: “Structure of a monomeric mutant of the HIV-1 capsid protein”. Solution nmr, 3 pockets (best druggability 0.45). MolNFT v1 #43511 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2LF4
Type: protein
Length: 232 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gag polyprotein
UniProt: Q72497
Pockets: 3 · best druggability 0.45

Structure

solution nmr · 1 distinct chain · 58% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gag polyprotein	protein	232	58% helix, 3% strand	Q72497

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.45	0.79	24	empty
2	70	0.41	0.80	21	empty
3	91	0.39	0.76	26	empty

Compared structures

2LF4 · Structure of a monomeric mutant of the HIV-1 capsid protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q72497
Elsewhere: RCSB PDB 2LF4 · PDBe 2LF4 · UniProt Q72497

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