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MolNFT v1 · #43488 · protein + DNA

LEF1 hmg domain (from mouse), complexed with DNA (15BP), NMR, 12 structures

2LEF · DNA (5'-D(*CP*AP*CP*CP*CP*TP*TP*TP*GP*AP*AP*GP*CP*TP*C)- 3'): “LEF1 hmg domain (from mouse), complexed with DNA (15BP), NMR, 12 structures”. Solution nmr, 2 pockets (best druggability 0.40). MolNFT v1 #43488 on GenesisL1: 3D…

PDB
2LEF
Type
protein + DNA
Length
116 residues
Chains
3
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA (5'-D(*CP*AP*CP*CP*CP*TP*TP*TP*GP*AP*AP*GP*CP*TP*C)- 3'); DNA…
UniProt
P27782
Pockets
2 · best druggability 0.40

Structure

solution nmr · 3 distinct chains · 57% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
BDNA (5'-D(*CP*AP*CP*CP*CP*TP*TP*TP*GP*AP*AP*GP*CP*TP*C)- 3')dna15——
CDNA (5'-D(*GP*AP*GP*CP*TP*TP*CP*AP*AP*AP*GP*GP*GP*TP*G)- 3')dna15——
AProtein (lymphoid enhancer-binding factor)protein8657% helix, 0% strandP27782

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1710.400.8013empty
2910.380.7616empty

Interfaces

3 interfaces between chains.

  • C–A · 1081 Ų buried · 27 hydrogen bonds · protein-nucleic
  • B–A · 1051 Ų buried · 23 hydrogen bonds · protein-nucleic
  • B–C · 659 Ų buried · 79 hydrogen bonds · nucleic-nucleic

Compared structures

  • 2LEF · LEF1 hmg domain (from mouse), complexed with DNA (15BP), NMR, 12 structures · the same entry in another collection · chain B against B, TM-score 1.00
  • P27782 · AlphaFold monomer V2.0 prediction for lymphoid enhancer-binding factor 1 (P27782) · a predicted model of the same protein · chain A against A, TM-score 0.81

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