MolNFT v1 · #43095 · protein

Solution NMR structure of the ERBB4 dimeric membrane domain

2L2T · Receptor tyrosine-protein kinase erbb-4: “Solution NMR structure of the ERBB4 dimeric membrane domain”. Solution nmr, 1 pocket (best druggability 0.32). MolNFT v1 #43095 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2L2T
Type: protein
Length: 88 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor tyrosine-protein kinase erbb-4
EC: 2.7.10.1
UniProt: Q15303
Pockets: 1 · best druggability 0.32

Structure

solution nmr · 1 distinct chain · 59% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Receptor tyrosine-protein kinase erbb-4 (EC 2.7.10.1)	protein	44	59% helix, 0% strand	Q15303

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.32	0.77	18	empty

Interfaces

1 interface between chains.

A–B · 564 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2L2T · Solution NMR structure of the ErbB4 dimeric membrane domain · the same entry in another collection · chain A against A, TM-score 1.00
Q15303 · AlphaFold monomer V2.0 prediction for receptor tyrosine-protein kinase erbb-4 (Q15303) · a predicted model of the same protein · chain A against A, TM-score 0.61

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15303
Elsewhere: RCSB PDB 2L2T · PDBe 2L2T · UniProt Q15303

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