MolNFT v1 · #43075 · protein

Solution structure of lactobacillus casei dihydrofolate reductase apo- form, 25 conformers

2L28: “Solution structure of lactobacillus casei dihydrofolate reductase apo- form, 25 conformers”. Solution nmr, 1 pocket (best druggability 0.76). MolNFT v1 #43075 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2L28
Type: protein
Length: 162 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dihydrofolate reductase
EC: 1.5.1.3
UniProt: P00381
Pockets: 1 · best druggability 0.76

Structure

solution nmr · 1 distinct chain · 20% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dihydrofolate reductase (EC 1.5.1.3)	protein	162	20% helix, 35% strand	P00381

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	509	0.76	0.83	45	empty

Compared structures

2L28 · Solution structure of lactobacillus casei dihydrofolate reductase apo-form, 25 conformers · the same entry in another collection · chain A against A, TM-score 1.00
P00381 · AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P00381) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00381
Elsewhere: RCSB PDB 2L28 · PDBe 2L28 · UniProt P00381

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