UniProt P00381
P00381
P00381 (UniProt P00381): 20 experimental structures and 1 predicted model on GenesisL1. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00381
- Experimental structures
- 20
- Predicted models
- 1
Structures
21 records of P00381 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AO8 | Dihydrofolate reductase complexed with methotrexate, NMR, 21 structures | solution nmr | A | — | — |
| 1AO8 | Dihydrofolate reductase complexed with methotrexate, NMR, 21 structures | solution nmr | A | — | — |
| 1BZF | NMR solution structure and dynamics of the complex of lactobacillus casei dihydrofolate reductase… | solution nmr | A | — | — |
| 1BZF | NMR solution structure and dynamics of the complex of lactobacillus casei dihydrofolate reductase… | solution nmr | A | — | — |
| 1DIS | Dihydrofolate reductase (E.C.1.5.1.3) complex with brodimoprim-4,6-dicarboxylate | solution nmr | A | — | — |
| 1DIS | Dihydrofolate reductase (E.C.1.5.1.3) complex with brodimoprim-4,6- dicarboxylate | solution nmr | A | — | — |
| 1DIU | Dihydrofolate reductase (E.C.1.5.1.3) complex with brodimoprim-4,6-dicarboxylate | solution nmr | A | — | — |
| 1DIU | Dihydrofolate reductase (E.C.1.5.1.3) complex with brodimoprim-4,6- dicarboxylate | solution nmr | A | — | — |
| 1LUD | Solution structure of dihydrofolate reductase complexed with trimethoprim and NADPH, 24 structures | solution nmr | A | — | — |
| 1LUD | Solution structure of dihydrofolate reductase complexed with trimethoprim and NADPH, 24 structures | solution nmr | A | — | — |
| 2HM9 | Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures | solution nmr | A | — | — |
| 2HM9 | Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures | solution nmr | A | — | — |
| 2HQP | Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures | solution nmr | A | — | — |
| 2HQP | Solution structure of L.CASEI dihydrofolate reductase complexed with NADPH, 32 structures | solution nmr | A | — | — |
| 2L28 | Solution structure of lactobacillus casei dihydrofolate reductase apo-form, 25 conformers | solution nmr | A | — | — |
| 2L28 | Solution structure of lactobacillus casei dihydrofolate reductase apo- form, 25 conformers | solution nmr | A | — | — |
| 2LF1 | Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures | solution nmr | A | — | — |
| 2LF1 | Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures | solution nmr | A | — | — |
| 3DFR | Crystal structures of escherichia COLI and lactobacillus casei dihydrofolate reductase refined at… | x-ray diffraction | A | — | — |
| 3DFR | Crystal structures of escherichia COLI and lactobacillus casei dihydrofolate reductase refined at… | x-ray diffraction | A | — | — |
| P00381 | AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P00381) | predicted | A | — | — |
Experiment against prediction
- 1DIU chain A against the predicted model P00381: TM-score 0.99, RMSD 0.34 Å
- 1DIU chain A against the predicted model P00381: TM-score 0.99, RMSD 0.34 Å
- 1DIS chain A against the predicted model P00381: TM-score 0.99, RMSD 0.34 Å
- 1DIS chain A against the predicted model P00381: TM-score 0.99, RMSD 0.34 Å
- 3DFR chain A against the predicted model P00381: TM-score 0.99, RMSD 0.29 Å
- 3DFR chain A against the predicted model P00381: TM-score 0.99, RMSD 0.29 Å
- 1AO8 chain A against the predicted model P00381: TM-score 0.96, RMSD 0.93 Å
- 1AO8 chain A against the predicted model P00381: TM-score 0.96, RMSD 0.93 Å
- 1LUD chain A against the predicted model P00381: TM-score 0.95, RMSD 1.13 Å
- 1LUD chain A against the predicted model P00381: TM-score 0.95, RMSD 1.13 Å
Elsewhere
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