MolNFT v1 · #42797 · protein
Solution structure of human vaccinia related kinase-1
2KTY · SERINE/THREONINE-protein kinase VRK1: “Solution structure of human vaccinia related kinase-1”. Solution nmr, 4 pockets (best druggability 0.60). MolNFT v1 #42797 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2KTY
- Type
- protein
- Length
- 360 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase VRK1
- EC
- 2.7.11.1
- UniProt
- Q99986
- Pockets
- 4 · best druggability 0.60
Structure
solution nmr · 1 distinct chain · 36% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase VRK1 (EC 2.7.11.1) | protein | 360 | 36% helix, 14% strand | Q99986 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 204 | 0.60 | 0.81 | 24 | empty |
| 2 | 128 | 0.48 | 0.79 | 22 | empty |
| 3 | 141 | 0.45 | 0.76 | 24 | empty |
| 4 | 53 | 0.36 | 0.79 | 14 | empty |
Compared structures
- 2KTY · Solution Structure of human Vaccinia Related Kinase-1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q99986 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase VRK1 (Q99986) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99986
- Elsewhere: RCSB PDB 2KTY · PDBe 2KTY · UniProt Q99986
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