MolNFT v1 · #42795 · protein

Human ERF1 C-domain, "open" conformer

2KTV · Eukaryotic peptide chain release factor subunit 1: “Human ERF1 C-domain, "open" conformer”. Solution nmr, 2 pockets (best druggability 0.33). MolNFT v1 #42795 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2KTV
Type: protein
Length: 164 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic peptide chain release factor subunit 1
UniProt: P62495
Pockets: 2 · best druggability 0.33

Structure

solution nmr · 1 distinct chain · 37% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic peptide chain release factor subunit 1	protein	164	37% helix, 23% strand	P62495

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.33	0.75	17	empty
2	57	0.32	0.76	11	empty

Compared structures

2KTV · Human eRF1 C-domain, open" conformer" · the same entry in another collection · chain A against A, TM-score 1.00
P62495 · AlphaFold monomer V2.0 prediction for eukaryotic peptide chain release factor subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62495
Elsewhere: RCSB PDB 2KTV · PDBe 2KTV · UniProt P62495

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