MolNFT v1 · #42521 · protein

Solution structure of the calcium binding domain of the C-terminal cytosolic domain of polycystin-2

2KLD: “Solution structure of the calcium binding domain of the C-terminal cytosolic domain of polycystin-2”. Solution nmr, 1 pocket (best druggability 0.46). MolNFT v1 #42521 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2KLD
Type: protein
Length: 73 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polycystin-2
UniProt: Q13563
Pockets: 1 · best druggability 0.46

Structure

solution nmr · 1 distinct chain · 32% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polycystin-2	protein	73	32% helix, 5% strand	Q13563

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	164	0.46	0.76	24	empty

Compared structures

2KLD · Solution Structure of the Calcium Binding Domain of the C-terminal Cytosolic Domain of… · the same entry in another collection · chain A against A, TM-score 1.00
Q13563 · AlphaFold monomer V2.0 prediction for polycystin-2 (Q13563) · a predicted model of the same protein · chain A against A, TM-score 0.42

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13563
Elsewhere: RCSB PDB 2KLD · PDBe 2KLD · UniProt Q13563

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