MolNFT v1 · #42220 · protein
NMR solution structure of complete receptor binding domain of human apolipoprotein E
2KC3: “NMR solution structure of complete receptor binding domain of human apolipoprotein E”. Solution nmr, 3 pockets (best druggability 0.52). MolNFT v1 #42220 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2KC3
- Type
- protein
- Length
- 183 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apolipoprotein E
- UniProt
- P02649
- Pockets
- 3 · best druggability 0.52
Structure
solution nmr · 1 distinct chain · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apolipoprotein E | protein | 183 | 71% helix, 0% strand | P02649 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.52 | 0.88 | 18 | empty |
| 2 | 126 | 0.46 | 0.78 | 29 | empty |
| 3 | 53 | 0.34 | 0.78 | 13 | empty |
Compared structures
- 2KC3 · NMR solution structure of complete receptor binding domain of human apolipoprotein E · the same entry in another collection · chain A against A, TM-score 1.00
- P02649 · AlphaFold monomer V2.0 prediction for apolipoprotein E (P02649) · a predicted model of the same protein · chain A against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02649
- Elsewhere: RCSB PDB 2KC3 · PDBe 2KC3 · UniProt P02649
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