MolNFT v1 · #42150 · protein

EPHA2 dimeric structure in the lipidic bicelle at pH 5.0

2K9Y · Ephrin type-a receptor 2: “EPHA2 dimeric structure in the lipidic bicelle at pH 5.0”. Solution nmr, 1 pocket (best druggability 0.32). MolNFT v1 #42150 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2K9Y
Type: protein
Length: 82 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ephrin type-a receptor 2
EC: 2.7.10.1
UniProt: P29317
Pockets: 1 · best druggability 0.32

Structure

solution nmr · 1 distinct chain · 51% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ephrin type-a receptor 2 (EC 2.7.10.1)	protein	41	51% helix, 0% strand	P29317

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.32	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 546 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2K9Y · EphA2 dimeric structure in the lipidic bicelle at pH 5.0 · the same entry in another collection · chain A against A, TM-score 1.00
P29317 · AlphaFold monomer V2.0 prediction for ephrin type-a receptor 2 (P29317) · a predicted model of the same protein · chain B against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29317
Elsewhere: RCSB PDB 2K9Y · PDBe 2K9Y · UniProt P29317

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.