MolNFT v1 · #42141 · protein

Structure of the core binding domain of SIGMA54

2K9M · RNA polymerase sigma factor rpon: “Structure of the core binding domain of SIGMA54”. Solution nmr, 2 pockets (best druggability 0.51). MolNFT v1 #42141 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2K9M
Type: protein
Length: 130 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA polymerase sigma factor rpon
UniProt: O66858
Pockets: 2 · best druggability 0.51

Structure

solution nmr · 1 distinct chain · 54% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA polymerase sigma factor rpon	protein	130	54% helix, 2% strand	O66858

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.51	0.81	26	empty
2	76	0.40	0.78	17	empty

Compared structures

2K9M · Structure of the Core Binding Domain of sigma54 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O66858
Elsewhere: RCSB PDB 2K9M · PDBe 2K9M · UniProt O66858

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