MolNFT v1 · #42073 · protein + DNA
Haddock calculated model of the complex between the brct region of rfc P140 and dsdna
2K7F · Replication factor C subunit 1: “Haddock calculated model of the complex between the brct region of rfc P140 and dsdna”. Solution nmr, 2 pockets (best druggability 0.65). MolNFT v1 #42073 on GenesisL1: 3D structure, binding sites…
- PDB
- 2K7F
- Type
- protein + DNA
- Length
- 133 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replication factor C subunit 1; 5'-D(P*DCP*DGP*DAP*DCP*DCP*DTP*DCP*DGP*DAP*DGP*DAP*DTP*DCP…
- UniProt
- P35251
- Pockets
- 2 · best druggability 0.65
Structure
solution nmr · 3 distinct chains · 33% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replication factor C subunit 1 | protein | 109 | 33% helix, 12% strand | P35251 |
| B | 5'-D(P*DCP*DGP*DAP*DCP*DCP*DTP*DCP*DGP*DAP*DGP*DAP*DTP*DCP* da)-3' | dna | 14 | — | — |
| C | 5'-D(P*DCP*DTP*DCP*DGP*DAP*DGP*DGP*DTP*DCP*DG)-3' | dna | 10 | — | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 249 | 0.65 | 0.83 | 30 | empty |
| 2 | 55 | 0.31 | 0.77 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–B · 645 Ų buried · 13 hydrogen bonds · protein-nucleic
- B–C · 591 Ų buried · 57 hydrogen bonds · nucleic-nucleic
- A–C · 397 Ų buried · 17 hydrogen bonds · protein-nucleic
Compared structures
- 2K7F · HADDOCK calculated model of the complex between the BRCT region of RFC p140 and dsDNA · the same entry in another collection · chain A against A, TM-score 1.00
- P35251 · AlphaFold monomer V2.0 prediction for replication factor C subunit 1 (P35251) · a predicted model of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35251
- Elsewhere: RCSB PDB 2K7F · PDBe 2K7F · UniProt P35251
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